Ukuthi Abesilisa Nabesifazane Bacubungula Kanjani Izikhumbuzo

Ngabasebenzi Brain & Behaeve

Abesilisa nabesifazane banokuthambekela okuhlukile kokuhlukumezeka- kanye nokuphazamiseka okuhlobene nengcindezi njengokukhathazeka kanye ne-post-traumatic stress disorder (PTSD), izifundo ezedlule zivezile. Isibonelo, abesifazane baba ne-PTSD kabili isilinganiso samadoda. Abaphenyi bafuna ukwazi ukuthi kungani lokhu kunjalo.

Ubufakazi obukhulayo bukhombisa ukuthi abesilisa nabesifazane bacubungula izinkumbulo ngokuhlukahluka. Ucwaningo olusha kumagundane oluvela eqenjini eliholwa ngu-2016 BBRF Umphenyi Omncane u-Elizabeth A. Heller, Ph.D., wase-University of Pennsylvania, usungula ezinye zezindlela ezibandakanyekile. Ukuqonda lezi zinqubo kungasiza ekwakhiweni kwesikhathi esizayo kwezokwelapha eziqondene nocansi zezinkinga zokukhathazeka.

Okutholwe yithimba kwakamuva kwabikwa ku-inthanethi kwiBiological Psychiatry ngoDisemba 5, 2018. Basikisela ukuthi ukulawulwa kofuzo olubizwa ngeCdk5 kungumthombo obalulekile womehluko endleleni abesilisa nabesifazane abenza ngayo izinkumbulo zokwesaba. Umehluko ubonwe ku-hippocampus yobuchopho, isikhungo sokwakheka kwememori, ukufunda, nokuma kwendawo.

Ukuziphendukela kwemvelo kuye kwaveza izindlela ezahlukahlukene amaseli alawula ngazo ukusebenza kwezakhi zofuzo — indlela ezivula futhi zicime ngayo ngezikhathi ezithile. Indlela yokulawula efanele i-Cdk5 nokucutshungulwa kwezinkumbulo zokwesaba ibizwa ngokuthi umthetho we-epigenetic. Lolu hlobo lokulawulwa kwezakhi zofuzo ngumphumela wokuguqulwa kwamangqamuzana, abizwa ngama-epigenetic marks, afakwa noma asuswe ekulandelaneni kwe-DNA "okupela" izakhi zofuzo. Ngokwengeza noma ngokususa amamaki e-epigenetic, amaseli ayakwazi ukwenza kusebenze noma avale izinhlobo ezithile zofuzo.

Kusetshenziswa amagundane njengabameleli babantu — ubuchopho begundane bufana kakhulu ezicini eziningi, kufaka phakathi izinqubo zokulawulwa kwezakhi zofuzo — uDkt. UHerer nozakwabo bathole ukuthi ukubuyisa izinkumbulo zesaba isikhathi eside kunamandla kwabesilisa kunabesifazane. Isizathu: ukukhulisa ukusebenza kwe-Cdk5 kwabesilisa, kubangelwa amamaki we-epigenetic. Ukwenza kusebenze kwenzeka kumaseli ezinzwa ku-hippocampus.

Kusetshenziswa inqubo yamanoveli ebizwa ngokuhlelwa kwe-epigenetic, uDkt Heller nozakwabo bakwazi ukuthola indima eqondene nabesifazane yokwenza kusebenze kwe-Cdk5 ekwenzeni buthakathaka ukubuyiswa kwezinkumbulo zokwesaba. Lokhu kube nemiphumela eqondene nabesifazane ochungechungeni lwezenzo zezinto ezilandela ukwenziwa kofuzo.

Lokhu okutholakele kuyingxenye yokuqonda kwethu okukhulayo kokwehluka kobulili kwi-biology yokuthi izehlakalo ezesabekayo zikhunjulwa kanjani futhi kusikisela ukuthi kungani ucansi luyinto ebalulekile ekuphazamisekeni kobuchopho nokuziphatha okubandakanya ukwesaba nokucindezeleka, okufana ne-PTSD, ukudangala nokukhathazeka.