I-Testosterone Ephansi, Ukukhuluphala Nezifo Ze-Alzheimer Kuxhunyiwe

Njengoba amadoda ekhula izinto ezimbili zivame ukwenzeka: amazinga e-testosterone awe futhi ukhalo lukhula. Amazinga e-testosterone ehla cishe ngephesenti elilodwa njalo ngonyaka ngemuva kweminyaka yobudala engama-30 ngenkathi ukukhuluphala phakathi kwabantu asebekhulile sekukhule kusuka cishe ku-8% ngo-1980 kuya ku-25% namuhla. Lezi zenzakalo ezimbili zithonya kabi ukusebenza okuvamile kobuchopho. I-testosterone ephansi ihlotshaniswe nokukhubazeka kwengqondo okuhlobene nobudala okungahle kube ngenxa yezinguquko endleleni ama-neuron ahlangana ngayo ezingeni lamaselula nokuthi ngabe ama-neurons athile asinda ekuchayekeni kobuthi noma ukulimala. Ngaphezu kwalokho, amazinga aphansi e-testosterone ayingcuphe yokuthuthukisa isifo i-Alzheimer's. Kwabesilisa abahlushwa isifo sikashukela, labo abanamazinga aphansi e-testosterone bavame ukukhombisa ama-neuropathies amaningi.

Ukukhuluphala ngokweqile, ikakhulukazi kwabadala, kuyisici esiyingozi enkulu ekwakhiweni kwesifo esesabekayo se-metabolic esifaka phakathi ama-lipids egazi aphakeme namazinga e-insulin kanye nokungabekezelelani kweglucose. Ukukhuluphala futhi kukhuphula izinga lamaprotheni avuvukalayo futhi, ngokuxakayo, izinguquko ze-endocrine eziholela ekwehliseni amazinga e-testosterone. Ukukhuluphala okuhambisana nokudla okunamafutha amaningi nakho kukhonjisiwe ukusheshisa ukwehla kokucabanga, ukufunda nokukhumbula kanye nokukwazi ukunaka.

Ucwaningo lwakamuva olushicilelwe ku- Ijenali yeNeuroinfigueation ososayensi abavela e-University of Southern California baphenye ubudlelwano phakathi kokuguga, ukukhuluphala ngokweqile, i-testosterone ephansi kanye nokwehla kwengqondo okuhambisana nokuwohloka komqondo. Kalula nje, ukudla okunamafutha amaningi okuholela ekukhuluphaleni kuzokwandisa imiphumela emibi ye-testosterone ephansi ekusebenzeni kobuchopho. Imiphumela yocwaningo iphinde ikhombise ukuthi into eyodwa ebalulekile ebuchosheni nasekugugeni komzimba, okungukuthi umthetho ongasebenzi kahle wokuvuvukala, uxhuma imiphumela yokukhuluphala namazinga aphansi e-testosterone nesifo i-Alzheimer's. Kuyathakazelisa ukuthi isifundo sabo asitholanga ukuthi amazinga aphansi e-testosterone athinta kakhulu isisindo somzimba.

Lokhu okutholakele kusikisela izindlela ezimbili zokwelashwa ezingaba khona: ukwelashwa okubuyisela i-testosterone kuyimpikiswano, kanti okunye, ukudla okunomkhawulo wekhalori, akunjalo. Ngonyaka odlule ucwaningo olushicilelwe ku- Ijenali ye-American Medical Association ithole ukuthi izithasiselo ze-testosterone zibeka abesilisa engcupheni yokufa, yokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. Namuhla, ukuphela kwamaqembu asekela ukusebenzisa lezi zithasiselo ngabakhiqizi abanethemba lokwenza inzuzo ngokungazi nokudideka, kungakhathalekile ukuthi lokhu kubabeka engcupheni engakanani abantu abathatha izithasiselo. Sonke siyakhumbula ukuthi le ndlela yokulwa nesayensi yake yasebenza kahle kangakanani embonini kagwayi.

Ngakho-ke yini indoda endala ekhuluphele okufanele iyenze? Ungathathi izithasiselo ze-testosterone! Isixazululo esingcono kakhulu ukwehlisa isisindo esingeqile ngokudla amakhalori ambalwa kakhulu. Ngeshwa, ukuzivocavoca kukodwa ngeke kuphumelele kakhulu ngoba amazinga aphansi e-testosterone avame ukuhlotshaniswa nobuthakathaka bemisipha kanye ne-atrophy. Namuhla, ubuningi obuningi bobufakazi besayensi obuthinta imikhakha ebanzi yezokwelapha buphikisa ngokuqinile ukuthi ukukhuluphala ngokweqile kusheshisa inqubo yokuguga, kuphazamise ukusebenza kwengqondo konke futhi, ekugcineni, kubhekene nezinqubo eziningi ezisibulalayo. Izindaba ezimnandi ukuthi imiphumela yokuvuvukala ngenxa yokukhuluphala kungenzeka ikhule kancane futhi idinga iminyaka eminingi ukuthi ivezwe ngokugcwele. Ngakho-ke, noma ngabe uneminyaka emingaki, ukusheshe ulahlekelwe amanoni ngokushesha ingqondo nomzimba wakho kungaqala ukubuyela esimweni. Le nto engcupheni iyavikeleka!

© Gary L. Wenk, Ph.D. Umbhali we Ubuchopho bakho ekudleni (I-Oxford University Press)

Inkulumo ye-TED: youtube.com